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Research and Development
List of Patents and Utility Models

List of patents and utility model rights where the applicant at the time of filing was the Advance Group or individuals such as Advance officers.

  • The official gazette will be the registration gazette, or, in the case of a time when there was no registration gazette, the public notice gazette will be attached.
  • This includes cases where the current rights holder has changed due to transfer or other reasons.
  • The patent publications and utility model publications listed are presented solely as technical documents.

*1 Related to "Cyrax"

  • Utility Model Registration No. 1570712 (Utility Model Publication No. 56-46756): Low-Frequency Therapy Device By combining a coil and a pulse oscillation circuit, it became possible to adjust the voltage that stimulates the body, resulting in a compact low-frequency therapy device that does not require a transformer.
    This led to the widespread adoption of low-frequency therapy devices for home use.
  • Utility Model Registration No. 1442740 (Utility Model Publication No. 56-46756): Low-Frequency Therapy Device
  • Utility Model Registration No. 1471208 (Utility Publication No. 57-22921): Low-Frequency Therapy Device
  • Utility Model Registration No. 1399050 (Utility Model Publication No. 56-4016): Low-Frequency Therapy Device
  • Utility Model Registration No. 1452155: Low-frequency therapy device utilizing a relaxation circuit.

*2 "Papyrus"

  • Patent No. 1580707: Ionized water generator
    By creating a space (cathode downcomer) on the anode side opposite the cathode, it became possible to generate alkaline ionized water with a stable pH even in a home-use device. Thisrepresents the first step towards popularizing ionized water generators for home use.t low-frequency therapy device that does not require a transformer.
    This led to the widespread adoption of low-frequency therapy devices for home use.
  • Utility Model Registration No. 1434077: Continuous Ionized Water Generator.

*3 "Cambrem"

  • Patent No. 1077169: Coffee bean roasting machine
    We propose a coffee bean roaster that incorporates a temperature-sensing element in the roasting section, allowing for control of both roasting and cooling temperatures, making it suitable for home use. This device aims to enable people to enjoy authentic coffee at home.

*4 "Lectroad"

  • Patent 1108271: Medical electrodes
    This bioelectrode features a conductive and adhesive gel base material primarily composed of polysaccharides such as karaya gum and polyhydric alcohols. It was the first bioelectrode proposed that does not cause skin irritation or rashes and is suitable for children, and it is still used in medical institutions today.
  • Utility Model Registration No. 1754477 (Japanese Utility Model Publication No. 63-17455): Medical electrode with disposable interface member.
  • Utility Model Registration No. 1893748 (Utility Model Public Notice No. 3-6363) Biomedical Electrode
  • Utility Model Registration No. 1702203 (Utility Model Publication No. 62-3124) Biomedical Electrode
  • Patent No. 1485703: Medical electrodes
  • Patent No. 1686991: Medical electrodes
  • Patent 1560271 Bioelectrode
  • Patent No. 1661655: Method for manufacturing an interface substrate for bioelectrodes.
  • Patent No. 1712664: Biomedical electrodes
  • Patent No. 1712665: Biomedical electrodes
  • Patent No. 1970635 Conductive Adhesive Gel
  • Patent No. 2806594: Conductive adhesive gel for medical use
  • Patent No. 2716361: Printed electrodes for biomedical use
  • Patent No. 2718519: Conductive adhesive for medical use

*5 "Cylax GL" *6 "Glanz"

  • Utility Model Registration No. 1834491: Low-frequency therapy device
  • Patent 1162741: Low-frequency therapy device controlled by stored program.
    This low-frequency therapy device adjusts the intensity and timing of electrical stimulation by controlling the pulse width and pulse interval of the drive output drive pulses generated by the computer.
    It has evolved into a low-frequency therapy device with enhanced functionality to satisfy users, promoting its widespread use in homes.

*7 "Hemin"

  • Patent 1511327: Tobacco filter
    This cigarette filter contains hemin, which adsorbs mutagenic substances, including carcinogenic ones, found in tobacco.
    It pursued a new approach to health-conscious smoking and stood out from other cigarette filters at the time.
  • Utility Model Registration No. 1677405: Smoking Pipe

*8 "Ion-phorese"

  • Patent 1620191: Ion-phorese device
    In an Ion-phorese system that uses electrical output to deliver drugs into the body through the skin, the device features a depolarization configuration that eliminates the electrical charge accumulated in the skin during electrical stimulation, preventing burns and promoting transdermal drug delivery.
    This proposal offers a new approach to medical care by guiding drug delivery in a more patient-friendly manner.
  • Patent 1675180 Plaster structure for Ion-phorese
  • Patent No. 1621228: Electrode for Ion-phorese and plaster structure thereof.
  • Patent No. 1717021: Device for Ion-phorese
  • Patent No. 1955233: Electrode for Ion-phorese
  • Patent No. 1705614: Abrasive material for keratinization in Ion-phorese
  • Patent No. 1876224: Skin injury device for transdermal drug delivery.
  • Patent No. 2063694: Skin treatment agent for transdermal drug delivery.
  • Patent No. 1684051: Device for Ion-phorese
  • Patent No. 2834157: Device for Ion-phorese
  • Patent 2792660 Interface for Ion-phorese
  • Patent No. 2792663: Electrode for Ion-phorese
  • Patent No. 2703035: Ion-phorese device
  • Patent No. 2795452 Interface for Ion-phorese
  • Patent 2795453 Interface for Ion-phorese
  • Patent No. 2839279: Ion-phorese device
  • Patent No. 2820268: Skin treatment material for transdermal drug delivery.
  • Patent No. 2845490: Bioelectrode for skin treatment
  • Patent 2795458: Interface for electrical transdermal drug delivery
  • Patent 2845501 Interface for Ion-phorese
  • Patent No. 2798272 Interface for Ion-phorese
  • Patent 2845509 Interface for Ion-phorese
  • Patent 2818050 Interface for Ion-phorese
  • Patent 2818075 Interface for Ion-phorese
  • Patent No. 2856551: Ion-phorese device
  • Patent No. 3761201: Device for Ion-phorese
  • Patent 2818771 Interface for Ion-phorese
  • Patent No. 2909483 Skin treatment agent for Ion-phorese

*9 "Coccus"

  • Patent No. 1851153: Intestinal microbiota improving agent
    This oral administration product was developed using dead Streptococcus species (including Enterococcus species) and their extracts, which were found to improve the intestinal flora (promote the growth of beneficial bacteria, etc.). It was a pioneering product in the current market for functional processed foods primarily based on intestinal bacteria (lactic acid bacteria), and continues to be so today.
  • Patent 1921087 Cholesterol or triglyceride lowering agent
  • Patent No. 1826984: Method for producing a cholesterol-lowering active fraction and an anti-arteriosclerotic agent containing the active fraction.
  • Patent No. 1653782: Cholesterol-reducing active protein
  • Patent No. 2098063: Method for producing a cholesterol-lowering agent and food or beverage containing the agent.
  • Patent No. 1765919: Triglyceride-reducing active polysaccharides
  • Patent No. 1851161: Cholesterol-reducing active RNA fraction
  • Patent No. 1851166: Liver function improving agent
  • Patent No. 2136627: Anti-cancer agent
  • Patent No. 2690130: Lipid peroxide reducing agent
  • License No. 2939491 Functional Food
  • Patent No. 2903232: Lipid absorption inhibitors
  • Patent No. 2917037 ACAT inhibitor
  • Patent No. 3194267 Method for producing a salt excretion promoting composition
  • Patent 3064004 ACAT inhibitor
  • Patent No. 2969234 ACAT inhibitor
  • Patent No. 2756778: Food and beverages containing cholesterol-lowering agents
  • Patent No. 5308619 Health Food

*10 "Mupid"

  • Utility Model Registration No. 1772225: Simple Electrophoresis Apparatus
    By utilizing full-wave and half-wave rectification of commercial power supplies, this electrophoresis apparatus was extremely simple, easy to use, and unlike anything seen before. This compact, user-friendly, and reliable electrophoresis apparatus has become widespread throughout the world and continues to be so today.
  • Patent No. 3542688: Simple electrophoresis apparatus
  • Patent No. 3928769: Power supply for a simple electrophoresis apparatus
  • Patent No. 4798876: Electrophoresis apparatus
  • Patent No. 4098990: Small, simple electrophoresis apparatus
  • Patent No. 4262961: Gel seal for electrophoresis
  • Patent No. 4314079: Electrophoresis apparatus
  • Patent No. 4712364 Electrophoresis tank for electrophoresis apparatus
  • Patent No. 4814216: Barrier structure for electrophoresis and electrophoresis apparatus
  • Utility Model Registration 2021316: Operating Lid for Electrophoresis Apparatus

*11 "Bio-terminals"

  • Patent 1588911 Biomedical terminals
    A hydroxyapatite-based terminal that penetrates both inside and outside the body. It significantly reduces patient burden by allowing catheter use in an infection-free environment and eliminating the pain of needle insertion, proposing new medical applications such as home healthcare.
  • Patent No. 1687818: Bio-terminal for drug therapy system
  • Patent No. 1564376: Bio-terminal for drug therapy system
  • Patent 1649242 Bio-terminal
  • Patent No. 1698709 Antithrombotic Materials
  • Patent No. 1884815: Percutaneous implant
  • Patent 1760173 Bio-terminal
  • Patent No. 1897242: Translucent bioterminal
  • Patent No. 1921109: Biomedical terminals
  • Patent No. 2787828 Translucent bioterminal
  • Patent No. 2732272: Biomedical terminal structure
  • Utility Model Registration No. 1888282 (JUTHEN 03-11009) Biomedical Terminal Protector

*12 "halter electrocardiograph"

  • Patent No. 1939654: Signal Processing Method
    A method for compressing electrocardiogram waveforms when recording long-term electrocardiograms to digital memory. This was the first proposal for a memory-based recording device, now commonplace, that enables the miniaturization and compactness of 24-hour electrocardiogram recording devices.
  • Patent No. 1727834: Abnormal electrocardiogram recognition device
  • Patent No. 1649228: Abnormal electrocardiogram recognition device
  • Patent No. 1683980: Biosignal Processing Method
  • Patent No. 1815929: Long-term electrocardiogram recording method
  • Patent No. 1817947: Biosignal artifact detection device
  • Patent No. 1984350: Biosignal artifact detection device

*13 "Reflare"

  • Patent No. 1678929: Continuous Ionized Water Generator
    This device forms multiple through-holes in the anode, creating an alkaline water generation chamber and an acidic water generation chamber at the anode and cathode. Water is supplied to the alkaline water generation chamber formed at the anode to increase the efficiency of ionized water generation. It is a device that can combine ionized water generation and water purification functions, satisfying both a sense of security regarding water and a health-conscious desire.
  • Patent No. 1678930: Continuous Ionized Water Generator

*14 "Intestinal bacteria for preventing tooth decay"

  • Patent No. 1765931: Anti-caries agent
    Because Lactobacillus fermentum (reuteri) dead cells are resistant to cariogenic effects, an oral administration method with the dead cells as the main component is available.
  • Patent No. 1808493: Anti-caries or anti-periodontitis agent
    This product uses MTA, an intracellular substance of intestinal bacteria with anti-cariogenic and anti-periodontal properties, as its main ingredient. It is a pioneering product that promotes oral health by improving the oral flora.

*15 "Leiden"

  • Patent No. 2130268: Small low-frequency therapy device
    We propose a low-frequency therapy device that is applied to the skin by combining a boost circuit that generates boosted pulses with a circuit that stores these boosted pulses to form low-frequency stimulation pulses, and then combining this combined circuit with an adhesive material that adheres to the skin. We propose a therapy device that is ultimately easy for patients to use, such as being able to be applied to the skin like a poultice.
  • Utility Model Registration No. 1675000: Low-Frequency Therapy Device
  • Patent No. 2669616 Skin-adhesive Low-Frequency Therapy Device Construction
  • Patent No. 2710331: Small Electrical Stimulator
  • Patent No. 2131382 Skin-adhesive Low-Frequency Therapy Device
  • Utility Model Registration No. 1919822: Ultra-compact electrical stimulation device structure
  • Utility Model Registration No. 1942944: Electrode for Low-Frequency Therapy Device
  • Utility Model Registration No. 2057518: Ultra-compact electrical stimulation device

*16 "KPS"

  • License 1984390 Password Key Shared Method
    This key-sharing system consists of a publicly available identifier that identifies each user, a secret shared-key algorithm that generates a secret shared key when the identifier is entered, and an algorithm that performs encryption and decryption using the shared key. It allows encryption and decryption simply by entering one's own identifier. This system provides an easy-to-use encryption and decryption system that requires no specialized knowledge, and proposes an encryption method suitable for consumer equipment such as office devices.
  • Patent No. 2980320: Cryptographic key sharing method in a communication system using ciphertext.

*17 "Microfluidic channels"

  • Patent 2014964: Electrodes for electrocellular fusion
  • Patent No. 1984393: Method for electrocellular fusion
  • Patent No. 1984394: Power supply for electrocellular fusion
  • Patent No. 2727316 Fluidized Integrated Element
    A microdevice formed on a substrate with micro-working areas that fuse microchannels and cells, perform chemical reactions, and manipulate genes. It is a pioneering example of current micro-electromechanical systems such as MEMS.
  • Patent No. 3277182: Molecular Patterning Method
  • Patent 3064001 Molecular fixation device
  • Patent No. 2727316 Fluidized Integrated Element
  • Patent No. 1984415 Cell Fusion Device
  • Patent No. 2687123 Microparticle Manipulation Device
  • Patent No. 2720152 Microparticle Manipulation Device
  • Patent No. 2720161: Cell deformability measuring device
  • Patent No. 2639952 Microparticle Accelerator
  • Patent No. 2709833 Molecular Weight Determination Apparatus
  • Patent No. 2756677: Apparatus for handling fine particles
  • Patent No. 3097932: Electrostatic chromatography apparatus
  • Patent No. 3282679: Method for determining DNA base sequences
  • Patent No. 3495777: Black film production apparatus
  • Patent No. 3791999: Liquid particulate handling device
  • Patent 3845184 Liquid holding container

*18 "Aladdin"

  • Patent No. 2723258: Small Electrical Stimulator
    This adhesive low-frequency therapy device uses a combination of a boost circuit to generate boosted pulses and a circuit to store those boosted pulses to form low-frequency stimulation pulses, with the boost and storage circuits being computer-controlled. By incorporating a microcontroller into a low-frequency therapy device that can be attached to the skin, it can perform the same functions as a handheld low-frequency therapy device, opening up a new field of therapy devices.
  • Patent No. 2617942: Skin-adhesive electrical stimulation device kit
  • Utility Model Registration No. 2580573: Skin-integrated adhesive low-frequency therapy device
  • Utility Model Registration No. 2584221: Remote-controlled low-frequency therapy device
  • Utility Model Registration No. 2584237: Small Low-Frequency Therapy Device

*19 "Windsord"

  • Patent No. 1747777: Biostimulator
    This stimulation device combines an AC generator that generates alternating current using pulses with a second AC generator that generates alternating current with a phase shift from the output AC of the first AC generator. By outputting the relatively high-frequency AC outputs of the AC generator and the second AC generator so that they intersect within the body, it generates interfered low-frequency stimulation within the body. This device realizes a battery-powered device for delivering interference wave stimulation to the body, which was previously only available as a large device using commercial power, resulting in a compact device that expands the range of home-use therapeutic devices.
  • Patent No. 1414508: Electrical Stimulation Device
  • Patent No. 1618098: Electrical Stimulation Device
  • Patent No. 1618105: Electrical Stimulation Device
  • Patent No. 1655535: Electrical Stimulation Device
  • Patent No. 1784684: Biostimulator
  • Patent 2010515: Biostimulator
  • Patent No. 1747778: Biostimulator
  • Patent No. 1784686: Electrical Stimulation Device
  • Patent 2010526: Electrical Stimulation Device
  • Utility Model Registration No. 2600406: Electrical Stimulator
  • Utility Model Registration No. 2149200 (JUTHEN 6-14758) Biomedical Electrode

*20 "Simple Blood Collection Device"

  • Utility Model Registration No. 2572823: Simple Blood Collection Device
    This blood collection device consists of a decompression chamber, a sealed chamber that applies the decompression to the skin to create a bulge, a puncture site for human insertion within this sealed chamber, and suction to draw out blood. Because it can be attached to the skin and allows for painless blood collection, it can alleviate the suffering of patients who are forced to undergo regular blood draws with injection needles.
  • Patent No. 2696708: Automatic blood collection device
  • Patent No. 3494183: Simple blood collection device
  • Patent No. 3593553: Simple blood collection device
  • Patent No. 3664496: Blood collection device

*21 "ALF"

  • Patent 1845906: Semiconductor laser blood flow meter
    By incorporating a focusing unit to reduce mode hops and other effects that occur during the output of a semiconductor laser, a stable laser beam is output to the body. The emergence of blood flow meters using highly safe semiconductor lasers has made blood flow measurement much easier.
  • Patent 3107559 Hemocytometer
  • Patent 3036557: Non-contact laser blood flow meter
  • Patent No. 3114312: Tissue oxygen flow meter
  • Patent No. 3478346: Biosignal Processing Device
  • Utility Model Registration No. 2541553: Probe Fixing Device for Laser Blood Flow Meter

*22 "Venus Pump"

  • Patent No. 2903280: Electrical Stimulation Device
    A device has been proposed that detects pulse wave signals and outputs diastolic electrical stimulation from the detected pulse waves. By applying electrical stimulation that does not obstruct arterial blood flow pumped into the body by the heart, while promoting venous blood flow which is otherwise only exerted by inertia, blood flow is promoted, resulting in a device that contributes to weight loss and overall health.
  • Patent No. 2782649: Electrical Stimulation Device
  • Patent No. 2732336: Electrical Stimulation Device
  • Patent No. 2964288: Electrical Stimulation Device
  • Patent No. 2978002: Electrical Stimulation Device
  • Patent No. 2756747: Biosignal detection type stimulator
  • Patent No. 2964293: Pulse wave detection device
  • Utility Model Registration No. 2557076: Pulse Wave Detector

*23 "AQB Implant"

  • Patent No. 3198125: Method for manufacturing implants
    After coating the core material with calcium phosphate powder by thermal spraying, a crystallized apatite layer is formed by hydrothermal treatment. As a dental implant with early bone integration properties, it has established a prominent presence among dental implants worldwide and continues to do so today.
  • Patent No. 1827007: Method for manufacturing hydroxyapatite coated material
  • Patent No. 2520859: Method for manufacturing tricalcium phosphate coated material
  • Patent No. 2787829: Method for manufacturing calcium phosphate ceramic implants
  • Patent No. 2725194: Artificial tooth root
  • Patent No. 2975968: Method for forming a calcium phosphate coating layer
  • Patent No. 2952028: Artificial Teeth
  • Patent No. 3076636: Composite Implant
  • Patent No. 3076637: Composite Implant
  • Patent No. 3803140: Dental implant and method for manufacturing a dental implant
  • Patent No. 4365833: Method for manufacturing a dental implant and dental implant
  • Patent 5027967 Dental Implant
  • Patent 4109494: Method for manufacturing implants
  • Patent No. 5538463: Dental Implants
  • Patent No. 5891150: Method for manufacturing dental implants
  • Utility Model Registration No. 2593254: Rotating tool for dental treatment workpieces
  • Utility Model Registration No. 2593253: Holding device for dental treatment
  • Utility Model Registration No. 2591311: Ratchet Wrench for Dental Treatment

*24 "Eve Flora"

  • Patent 3606580 Cosmetics
    Cosmetics containing ingredients that promote the growth of resident skin bacteria, such as oleic acid triglycerides. At the time, skin treatments were only considered in terms of bactericidal action against resident skin bacteria. This product proposed the opposite idea of cultivating and maintaining the balance of resident bacteria, thus proposing a new field of cosmetics.
  • Patent No. 3579134 Cosmetics
  • Patent No. 3580453: Cell-activating cosmetic
  • Patent 3608059 Cosmetics
  • Patent No. 3771242 Cosmetics

*25 "Pleasure Slim"

  • Patent No. 3995852: Blood circulation promoting device
    The system detects pulse wave signals from the body, identifies the diastolic phase from these signals, and applies pneumatic stimulation during this phase. By promoting venous blood flow, which has no driving force, without obstructing arterial blood flow, it regulates and improves circulatory circulation, thus producing effects such as weight loss.

*26 "Cadim 105"

  • Patent No. 3482077: Method for manufacturing dental prostheses
    It features a three-dimensional measurement area that forms three-dimensional data while in contact with the surface of a dental prosthesis model, and a processing area that processes blocks based on the three-dimensional surface data obtained from the three-dimensional measurement area. This enables the creation of dental prostheses at the dental clinic level, resulting in faster and more cost-effective production.
  • Patent No. 3495760: Method for manufacturing removable dentures
  • Patent No. 3491922: Block for manufacturing removable dentures
  • Patent No. 4291897: Method for manufacturing dental prostheses
  • Patent 4011129: Method for manufacturing a dental crown substitute.
  • Patent No. 4464485: Method for processing dental prostheses
  • Patent No. 4674935: Method for vertically setting up measuring objects for dental prostheses.
  • Patent No. 4215893: Block for forming dental prostheses
  • Patent No. 4451817: Dental Technology Evaluation System

*27 "Kaguya Smart Crown"

  • Patent No. 4496050: Method for manufacturing blocks for processing dental prostheses
    This invention relates to a CAD/CAM processing block containing feldspar, nepheline cyanite, calcia, and yttria. The block undergoes frit treatment, crushing, and post-shaping/sintering to produce a highly aesthetically pleasing block. The aim is to propose a low-cost method for producing aesthetically pleasing prostheses, thereby reducing the cost of cosmetic dentistry.

*28 "RAntiS"

  • Patent No. 5414535: Method for producing single-chain antibody scFv
    After immunizing spleen cells and obtaining total-RNA, the antibody gene is amplified by PCR using specific primers, the target antibody gene is selected by electrophoresis, and single-chain antibodies (ScFv) are obtained from the selected antibody gene. Single-chain antibodies are then manufactured through a host cell expression process. This method allows for the low-cost production of various antibodies, contributing to the reduction of pharmaceutical costs.

*29 "Panocom"

  • Patent No. 5651132: Intraoral imaging and display system
    This system utilizes an intraoral camera with a reflector to capture continuous images of the oral cavity. By moving the intraoral camera along the dental arch and combining multiple images captured in rapid succession, a panoramic dental image is formed. This allows for the creation of a realistic panoramic dental image that is easy for patients to understand, and proposes a dental treatment approach that is more accessible to patients.
  • Patent No. 5543865: Intraoral imaging system
  • Patent No. 5593176: Intraoral imaging and display system
  • Patent No. 5815962: Dental Prosthesis Measurement and Processing System
  • Patent No. 5784381: Dental Treatment System
  • Patent No. 5869822: Dental Image Processing System